BDgene

SNP Report

Basic Info
Name rs6550435 dbSNP Ensembl
Location chr3:36822998 - 36822998(1)
Variant Alleles T/G
Ancestral Allele T
Minor Allele G
Minor Allele Frequence 0.330072
Functional Annotation downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript downstream_gene_variant(ENST00000429976, ENST00000631338); upstream_gene_variant(ENST00000623207, ENST00000623312)
No. of Studies 3 (Positive: 1; Negative: 0; Trend: 2)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Sklar, P.,2011 G/T Primary GWAS P-value(GC)=0.0000197, OR=1.12; replication P-v...... Primary GWAS P-value(GC)=0.0000197, OR=1.12; replication P-value(1-sided)=0.0326, OR=1.05; Combined GWAS and replication P-value(GC)=0.00000932, OR=1.09 More... Suggestive association was found. Suggestive association was found. Trend
Green, E. K.,2012 G/T BD ImmunoChip:P-value = 0.819,OR = 0.988;ImmunoChip, PGC-BD ...... BD ImmunoChip:P-value = 0.819,OR = 0.988;ImmunoChip, PGC-BD combined data:P-balue = 0.0000454,OR = 1.077 More... Suggestive association was found. Suggestive association was found. Trend
Muhleisen, T. W., 2014 G/T G MooDS: P-value=7.16E-4, OR=1.15; PGC: P-value=4.80E-6, OR=1....... MooDS: P-value=7.16E-4, OR=1.15; PGC: P-value=4.80E-6, OR=1.12; MooDS-PGC: P-value=1.54E-8, adjusted P-value=2.05E-8, OR=1.13 More... Eighteen GWAS SNPs showing genome-wide evidence for associat...... Eighteen GWAS SNPs showing genome-wide evidence for association with BD in the combined MooDS and PGC samples. More... Positive

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 3p22.2 5(2/1/2)

SNPs in LD with rs6550435 (count: 16) View in gBrowse (chr3:36801658..36854744 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 16)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)