SNP Report

Basic Info

Name	rs578776 dbSNP Ensembl
Location	chr15:78596058 - 78596058(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	G
Minor Allele Frequence	0.445288
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000326828); downstream_gene_variant(ENST00000299565, ENST00000394802, ENST00000559554, ENST00000559576, ENST00000624172); intron_variant(ENST00000348639, ENST00000559002, ENST00000559658); NMD_transcript_variant(ENST00000559658); non_coding_transcript_variant(ENST00000559002); upstream_gene_variant(ENST00000567141)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Hartz, S. M.,2011			X² test: for nicotine dependence with and without...... X² test: for nicotine dependence with and without bipolar disorder, allele P-value = 0.41; logistic regression: for BD case-control, P-value = 0.3, OR=0.92, 95% CI=0.8-1.1, when smoking as a covariate, P-value = 0.28, OR=0.92, for non-smokers only, P-value = 0.37, OR=0.91 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CHRNA5	cholinergic receptor, nicotinic, alpha 5 (neuronal)	15q24	3(2/1/0)
CHRNA3	cholinergic receptor, nicotinic, alpha 3 (neuronal)	15q24	3(1/2/0)

SNPs in LD with rs578776 (count: 0) View in gBrowse (chr15:78596058..78596058 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)