SNP Report

Basic Info

Name	rs3757933 dbSNP Ensembl
Location	chr8:32747325 - 32747325(1)
Variant Alleles	G/A
Ancestral Allele	A
Minor Allele	A
Minor Allele Frequence	0.292732
Functional Annotation	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000518206, ENST00000520407, ENST00000520502, ENST00000523041); intron_variant(ENST00000287842, ENST00000356819, ENST00000405005, ENST00000518084, ENST00000518104, ENST00000519240, ENST00000519301, ENST00000521670, ENST00000522402, ENST00000522569, ENST00000523079, ENST00000523534, ENST00000539990); non_coding_transcript_variant(ENST00000522569); upstream_gene_variant(ENST00000523681)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Cao L., 2014	A/G		Total BPI vs. controls: X²=8.82, OR=1.35, 95%CI=1...... Total BPI vs. controls: X²=8.82, OR=1.35, 95%CI=1.11-1.64, Bonf P-value=0.089; BPI-P vs. controls: X²=3.28, OR=1.23, 95%CI=0.98-1.54, Bonf P-value=1; BPI-NP vs. controls: X²=10.08, OR=1.65, 95%CI=1.21-2.25, Bonf P-value=0.045 More...	The results of the subgroup analysis showed an allele-wise s...... The results of the subgroup analysis showed an allele-wise significant but marginal association between rs3757933 (Ï‡²=10.08; OR=1.648; Bonf P-value=0.045) and an overrepresented allele A in BPI-NP. More...	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
NRG1	neuregulin 1	8p12	15(10/5/0)

SNPs in LD with rs3757933 (count: 22) View in gBrowse (chr8:32727339..32812746 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 22)

rs_ID	Functional Annotation	r²[population]
rs3735775	intron_variant; non_coding_transcript_variant	0.953[CHB]; 1.0[JPT]
rs13272435		0.804[CHB]; 0.857[JPT]
rs10087939	intron_variant; non_coding_transcript_variant	0.953[CHB]; 1.0[JPT]
rs10216730	intron_variant; non_coding_transcript_variant	1.0[CHB]; 0.952[JPT]
rs4556053		0.853[JPT]
rs10954866	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.95[CHB]; 1.0[JPT]
rs4733372	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs7812396	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CHB]; 1.0[JPT]
rs9297196	intron_variant; non_coding_transcript_variant	0.953[CHB]; 1.0[JPT]
rs3735776	intron_variant; non_coding_transcript_variant	0.949[CHB]; 1.0[JPT]
rs10105155	intron_variant; non_coding_transcript_variant	0.953[CHB]; 1.0[JPT]
rs4302804		0.814[CHB]; 0.811[JPT]
rs4733373	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs7840503	intron_variant; non_coding_transcript_variant	0.951[CHB]; 1.0[JPT]
rs13266765	downstream_gene_variant	0.804[CHB]; 0.805[JPT]
rs4445184		0.804[CHB]; 0.853[JPT]
rs7007436	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs10954870		0.862[JPT]
rs10089599	intron_variant; non_coding_transcript_variant	0.95[CHB]; 1.0[JPT]
rs4733376	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.804[CHB]; 0.805[JPT]
rs11780123		0.804[CHB]; 0.853[JPT]
rs16879886	intron_variant; non_coding_transcript_variant	0.95[CHB]; 1.0[JPT]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)