SNP Report

Basic Info

Name	rs3755486 dbSNP Ensembl
Location	chr2:174767158 - 174767158(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.282947
Functional Annotation	intron_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000442996, ENST00000636168); non_coding_transcript_variant(ENST00000442996); upstream_gene_variant(ENST00000261007, ENST00000348749, ENST00000409219, ENST00000409323, ENST00000409542, ENST00000435083)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Shi, J., 2007	C/T		TDT P-value = 0.43 of Allelic Association With Bipolar Disor...... TDT P-value = 0.43 of Allelic Association With Bipolar Disorder in the Combined Sample More...		Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	2q31.1	2(0/1/1)

SNPs in LD with rs3755486 (count: 4) View in gBrowse (chr2:174737238..174767158 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs3755485	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.959[CEU]; 0.911[TSI]
rs935866	intron_variant; non_coding_transcript_variant	0.85[CEU]; 0.802[TSI]
rs7560774	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]
rs2123117	intron_variant; non_coding_transcript_variant	0.808[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)