BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Region Report

Basic Info

Region Name	17q11
Chromosome Position	chr17:25100000-33500000
No. of Studies (Positive/Negative/Trend)	2(2/0/0)

Region related studies (count: 2)

Reference	Markers	Statistical Values	Author Comments	Result Category
Xu, H.,2011	D17S921, D17S900, D17S2196, D17S1303	Family-Based Association: For marker D17S900, for BP1, allel...... Family-Based Association: For marker D17S900, for BP1, allele 1, Z-score = -2.077, P-value = 0.037806, Perm.P-value = 0.04025; For marker D17S921, for BP1, allele 7, Z-score = 2.385, P-value = 0.017094, Perm.P-value = 0.018388; For marker D17S2196, for BP1, allele 5, Z-score = 2.151, P-value = 0.031474, Perm.P-value = 0.031252; Linkage study: For marker D17S921, for BP1, Dominant model, LOD = 1.22 for New pedigrees(N = 16), LOD = 0.85 for all pedigrees(N = 56); For marker D17S1303, for BP1, Dominant model, LOD = 0.83 for New pedigrees(N = 16), LOD = 2.07 for all pedigrees(N = 56); More...	Significant associations were found in BP1. Significant associations were found in BP1.	Positive
Xu, H.,2010	D17S921, D17S900, D17S2196, D17S1303	Association analysis: For marker D17S900, for BP1, allele 1,...... Association analysis: For marker D17S900, for BP1, allele 1, z-score = -2.077, FBAT P-value = 0.037806, perm P-value = 0.04025; For marker D17S921, for BP1, allele 7, z-score = 2.385, FBAT P-value = 0.017094, perm P-value = 0.018388; allele 3, z-score = -2.827, FBAT P-value = 0.004692, perm P-value = 0.004911;For marker D17S2196, for BP1, allele 5, z-score = 2.151, FBAT P-value = 0.031474, perm P-value = 0.031252; Global FBAT P-value = 0.021706, perm P-value = 0.031496; linkage study: For marker D17S921, for BP1, Dominant model, LOD = 1.22 in new pedigrees(N = 16); LOD = 0.85 in all pedigrees(N = 56); For marker D17S1303, for BP1, Dominant model, LOD = 0.83 in new pedigrees(N = 16); LOD = 2.07 in all pedigrees(N = 56) More...	Significant associations were found in BP1. Significant associations were found in BP1.	Positive

Region related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SLC6A4	solute carrier family 6 (neurotransmitter transporter), member 4	17q11.2	44(18/26/0)
NF1	neurofibromin 1	17q11.2	1(1/0/0)

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Region: chr17:25100000..33500000 View in gBrowse