Gene Report

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Basic Info

Approved Symbol	CBR3
Symbol Alias	SDR21C2
Approved Name	carbonyl reductase 3
Name Alias	short chain dehydrogenase/reductase family 21C, member 2
Location	21q22.2
Position	chr21:36134912-36146566, 1
External Links	HGNC: 1549 Entrez Gene: 874 Ensembl: ENSG00000159231 UCSC: uc002yve.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McQuillin, A.,2011		Gene related CNV occurred in two or more cases but not in controls.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0050890	cognition	biological process	IMP[23227193]	11
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0005829	cytosol	cellular component	IDA[18493841]	223
GO:0000253	3-keto sterol reductase activity	molecular function	IEA	1
GO:0004090	carbonyl reductase (NADPH) activity	molecular function	IDA[18493841]	1
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0070402	NADPH binding	molecular function	IDA[18493841]	3
GO:0042376	phylloquinone catabolic process	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00590	Arachidonic acid metabolism	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CBR3	ARIH2	NO	yeast 2-hybrid	16169070
CBR3	RAB35	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_McQuillin[2011]_26	chr21:36429132-36440730 (NCBI Build 36 (hg18))	11599

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 21	chr21:0-46709983	1 (0/1/0)
21q22	chr21:30200000-46709983	2 (0/0/2)
21q21.3-qter	chr21:25500000-46709983	1 (0/1/0)
21q21.1-q22.13	chr21:15000000-38300000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr21:36134912..36146566 View in gBrowse