Table 3 Categorization criteria of the statistical results

Study Type

Results Category a

Criteria

For GWAS

Positive

P < 1x10-7

Negative

P > 1x10-5

Trend

1x10-7 < P < 1x10-5

For general candidate-gene association study and meta-analysis

Positive

P < 0.05 at least for one analysis

Negative

P > 0.05 for all analyses

For linkage analysis b (1)

Positive

LOD > 3.3 at least for one analysis

Negative

LOD < 1.9 for all analyses

Trend

1.9 < LOD < 3.3 for all analysis

For mutational study c

Trend

 

a: literature-origin genes with at least one positive polymorphism were defined as ‘Positive’.

b: If other statistical values were used in linkage study instead of LOD, the criteria were referred to the Statistical Method in original papers.

c: Novel defined polymorphisms by mutational studies were classified as ‘Trend’ except a significant level was proposed.